Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node.
نویسندگان
چکیده
منابع مشابه
Heart rate : a simple yet complex concept -
The architecture of the sinus node, the atrioventricular conduction axis, and the internodal atrial myocardium R. H. Anderson and S. Y. Ho Multicentric origin of the atrial depolarization wave: the pacemaker complex. Relation to dynamics of atrial conduction, P-wave changes and heart rate control – J. P. Boineau and others Voltage-clamp investigations of membrane currents underlying pace-maker ...
متن کاملReconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments.
The pacemaker activity of the S-A node cell was explained by reconstructing the pacemaker potential using a Hodgkin-Huxley type mathematical model which was based on the reported voltage clamp data. In this model four dynamic currents, the sodium current iNa, the slow inward current, is, the potassium current, iK, and the hyperpolarization-activated current, ih, in addition to a time-dependent ...
متن کاملتأثیــر نیکــل بر مسدود کردن جریان یونــی گذرای کلسیمــی سلولهای گــره سینوسی ـ دهلیزی دست نخورده و سالم قلب خرگوش
The mammalian sino-atrial node is not a uniform tissue in histological and electrophysiological terms. The differences in ionic currents underlying the regional differences in electrial activity are only just beginning to be understood. One of the ionic currents it is thought to play a role in the center of sino-atrial node for action potential upstroke should be transient Ca+2 current ...
متن کاملChronotropic effect of nizofenone fumarate in rabbit sino-atrial node in vitro.
1. The effects of nizofenone fumarate were studied on the membrane potentials and currents of rabbit sino-atrial node preparations by means of the double-microelectrode voltage clamp method. 2. In spontaneously firing pacemaker cells, nizofenone (above 1 microM) decreased the heart rate. Above 3 microM, nizofenone reduced the maximum upstroke velocity, the amplitude of the action potential and ...
متن کاملAtrial tachycardia secondary to sino-atrial node reentry.
In one patient reprodncibk episodes of sMal tachyear(200 msec, control; 70 msec, atropine) and sustained dia conld be elicited via programmed atrial premature atrial tachycardia no longer could be elicited. These dcpoluizations. Evllodion of the elechpphysiologic studies mpport the concept that h a t t i a l reciprocation shldks suggested that the most tikely mechanism was can be a mechanism re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1980
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1980.sp013474